Department of Vascular Pathophysiology

Head of Department

RNDr. Soňa Čačányiová, PhD.

02 / 3229 6014

About the department

The Department of Vascular Pathophysiology is primarily focused on comprehensive monitoring of functional, structural, and molecular changes in the vascular system under normal and pathological conditions. Functional studies are carried out at the level of in vitro and in vivo experiments. We focus on monitoring the vasoactive properties of isolated large (supply) and small (resistance) vessels using the method of measuring changes in isometric tension (in vitro). At the level of in vivo experiments, we monitor the integrated response of the cardiovascular system (invasive measurement of blood pressure, heart rate, pulse wave determination) as well as blood flow through a selected vessel using a perivascular ultrasound system. Structural changes are studied using light microscopy (vessel wall thickness and area, immunohistochemistry). At the level of molecular changes, the expression of proteins involved in the regulation of blood pressure and cardiovascular disorders is studied, using the  immunofluorescence and fluorescence microscopy we monitor the localisation of proteins and enzymes within the vascular wall and perivascular adipose tissue.

Selected recent publications

BERÉNYIOVÁ, Andrea – CEBOVÁ, Martina – BASAK, Aydemir Gunes – GOLAS, Samuel – MAJZÚNOVÁ, Miroslava – ČAČÁNYIOVÁ, Soňa. Vasoactive effects of chronic treatment with fructose and slow-releasing H2S donor GYY-4137 in spontaneously hypertensive rats: The role of nitroso and sulfide signalization. In International Journal of Molecular Sciences, 2022, vol. 23, no., art. no. 9215. (2021: 6.208 – IF).

BERÉNYIOVÁ, Andrea – BALIŠ, Peter – KLUKNAVSKÝ, Michal – BERNÁTOVÁ, Iveta – ČAČÁNYIOVÁ, Soňa – PÚZSEROVÁ, Angelika. Age- and hypertension-related changes in NOS/NO/sGC-derived vasoactive control of rat thoracic aortae. In Oxidative medicine and cellular longevity, 2022, vol. 2022, article ID 7742509. (2021: 7.310 – IF).

GOLAS, Samuel – BERENYIOVA, Andrea – MAJZUNOVA, Miroslava – DROBNA Magdalena – TUORKEY, Muobarak J., – CACANYIOVA, Sona. Vasoactive Effect of Perivascular Adipose Tissue and Hydrogen Sulfide in Thoracic Aortas of Normotensive and Spontaneously Hypertensive Rats in Biomolecules : Open Access Journal, 2022, vol. 12, art. no 457. (2021: 6.064 IF)

ČAČÁNYIOVÁ, Soňa – GOLAS, Samuel – ZEMANČÍKOVÁ, Anna – MAJZÚNOVÁ, Miroslava – CEBOVÁ, Martina – MALINSKÁ, Hana – HÜTTL, Martina – MARKOVA, Irena – BERÉNYIOVÁ, Andrea. The vasoactive role of perivascular adipose tissue and the sulfide signaling pathway in a nonobese model of metabolic syndrome. In Biomolecules : Open Access Journal, 2021, vol. 11, no. 1, art. no. 108 (2020: 4.879 – IF).

TÖRÖK, Jozef – ZEMANČÍKOVÁ, Anna – VALÁŠKOVÁ, Zuzana – BALIŠ, Peter. The role of perivascular adipose tissue in early changes in arterial function during high-fat diet and its combination with high-fructose intake in rats. In Biomedicines, 2021, vol. 9, no. 11, art. no. 1552 (2020: 6.081 – IF).

ZEMANČÍKOVÁ, Anna – TÖRÖK, Jozef – BALIŠ, Peter – VALOVIČ, Pavol – ULIČNÁ, Oľga – CHOMOVÁ, Mária. Modulation of sympathoadrenergic contractions by perivascular adipose tissue in mesenteric arteries of rats with different level of body adiposity. In Journal of Physiology and Pharmacology: formerly Acta Physiologica Polonica, 2020, vol. 71, no. 4, p. 589-596. (2019: 2.644 – IF).

Current projects

APVV SK-CZ-RD-21-0102:  The role of inflammation in the development of cardiovascular complications associated with metabolic syndrome and prediabetes (1. 7. 2022 – 30. 6. 2025)

APVV-20-0421: Cardiometabolic effects of Mas receptor stimulation by modulation of the renin-angiotensin system – the key role of angiotensin-converting enzyme 2 (1.7. 2021-30.6.2025)

APVV-19-0154: Study of biological effects of H2S/NO/selenium products and molecular mechanisms of their actions (1.7. 2020 – 31. 6. 2024)

VEGA 2/0147/22: Zofenopril and erucin, H2S releasing coumpounds, in therapy of cardiovascular disorder in experimental model of obesity and 2 type diabetes (1.1. 2022 – 31. 12. 2025)

VEGA 2/0156/21: Mesenteric perivascular fat and its specific role in regulation of intestinal circulation in rats with different feeding regimens (1. 1. 2021 – 31. 12. 2023)

VEGA 2/0111/19: Vazoactive effects of hydrogen sulphide signalling pathway and its interaction with nitric oxide in different animal models of metabolic syndrome (1. 1. 2019 – 31. 12. 2022)

OCP in the media