Natural Psychoplastogens As Antidepressant Agents

Psilocybin – one of the most studied psychoplastogens.

Our colleagues Jakub Benko and Stanislava Vrankova published a review “Natural Psychoplastogens As Antidepressant Agents“. In it they summarise the up to date research on this newly defined drug class. The definition was put forward by Olson and colleagues based on a couple of research articles. They observed that several previously unrelated classes of drugs – serotonergic psychedelics, ketamine or 7,8-dihydroxyflavone – exert their neuroplastic effect through direct or indirect activation of TrkB receptors and mTOR kinase. In consequence, these compounds exert their antidepressant effect by improving impaired connectivity between neurons of depressed individuals. This is achieved also by conventional antidepressants (e.g. SSRIs) after chronic administration. In contrast, psychoplastogens exert their effect even after one acute dose, thus lowering potential non-compliance to treatment. Our colleagues further describe the molecular details of these substances and discuss their other advantages and disadvantages.